Compare Weight Loss Peptides
Head-to-head comparisons based on clinical trial data — not marketing claims. We use direct trial evidence where it exists, and note where cross-trial comparisons are involved.
#1 Comparison · Head-to-Head Trial Data Available
Tirzepatide vs. Semaglutide
The definitive head-to-head comparison
TirzepatideSemaglutide
47% more weight loss with tirzepatide (20.2% vs 13.7%) in the SURMOUNT-5 head-to-head trial.
See Full Comparison →Retatrutide vs. Tirzepatide
Triple agonist vs. dual agonist — evidence asymmetry explained
RetatrutideTirzepatide
Retatrutide showed 28.7% weight loss in TRIUMPH-4 Phase 3 vs. 22.5% for tirzepatide in SURMOUNT-1 — but no head-to-head trial exists and retatrutide is not yet FDA-approved.
See Full Comparison →Medical Disclaimer: This content is for educational purposes only. Clinical trial data reflects average outcomes — individual results vary. Consult a qualified healthcare provider before starting any medication.